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Bicalutamide and Sexual Function: Managing Side Effects

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27 Apr 2023

Bicalutamide and Sexual Function: Managing Side Effects

Understanding Bicalutamide and its Effects on Sexual Function

Bicalutamide is a medication commonly prescribed for men with advanced prostate cancer. Its primary function is to block the effects of testosterone, a hormone that can fuel the growth of prostate cancer cells. While this treatment can be effective in slowing down the progression of the disease, it can also have a significant impact on a man's sexual function, including libido and erectile function. In this section, we will explore the reasons behind these side effects and discuss ways to manage them.

How Bicalutamide Affects Testosterone Levels

Testosterone is a hormone that plays a crucial role in maintaining a man's sexual function. Bicalutamide works by binding to androgen receptors in the body, blocking testosterone from binding to these receptors. This effectively reduces the levels of testosterone in the body, which can result in a decrease in sexual desire and the ability to achieve and maintain an erection. It's important to understand that these side effects are a direct result of the medication's action on testosterone levels and are not indicative of any underlying issue with your overall health.

Managing Decreased Libido

Dealing with a decreased libido can be challenging, both physically and emotionally. The first step in managing this side effect is to communicate openly with your partner about your feelings and concerns. It's essential to remember that your relationship is not solely based on sexual intimacy. Engaging in non-sexual activities that promote closeness and emotional connection can help maintain the bond between you and your partner.

Additionally, consider discussing your concerns with your healthcare provider. They may be able to recommend alternative treatments or adjust your Bicalutamide dosage to minimize the impact on your libido. In some cases, supplemental testosterone therapy may be an option to help counteract the effects of Bicalutamide on your sexual desire.

Addressing Erectile Dysfunction

Erectile dysfunction (ED) is a common side effect of Bicalutamide, but it doesn't have to be a permanent issue. There are several treatment options available to help manage ED, including oral medications like sildenafil (Viagra) or tadalafil (Cialis). However, it's essential to consult with your healthcare provider before starting any new medication, as there may be potential interactions with your current treatment plan.

Other non-pharmacological options to consider include vacuum erection devices, penile injections, or penile implants. These methods can help restore erectile function and improve overall sexual satisfaction. Your healthcare provider can guide you in choosing the best option for your specific situation.

Dealing with Changes in Ejaculation and Fertility

Some men on Bicalutamide may experience a decrease in the volume of ejaculate or even complete absence of ejaculation. This can be a result of the medication's effect on the prostate gland and seminal vesicles. While this change may be distressing, it's essential to know that it doesn't necessarily affect your ability to achieve orgasm or experience sexual pleasure.

However, it's important to note that Bicalutamide can have a significant impact on fertility. If you're concerned about your ability to father a child, discuss this with your healthcare provider. They may recommend alternative treatments, or suggest sperm banking or other fertility preservation options before starting Bicalutamide therapy.

Exploring Alternative Treatments

If the sexual side effects of Bicalutamide are severely impacting your quality of life, it may be worth discussing alternative treatments with your healthcare provider. There are other medications and treatment options available for prostate cancer, and your provider can help you weigh the pros and cons of each approach to determine the best course of action for your specific situation.

Support and Counseling

Dealing with the sexual side effects of Bicalutamide can be emotionally challenging. It's important to seek support from friends, family, or support groups to help cope with these changes. Additionally, professional counseling or therapy, either individually or as a couple, can be beneficial in addressing the emotional impact of these side effects and helping you develop strategies to maintain a healthy and satisfying relationship.


While Bicalutamide can be an effective treatment for advanced prostate cancer, it's essential to be aware of the potential impact on sexual function. By understanding these side effects and exploring options for managing them, you can maintain a fulfilling and satisfying sex life throughout your treatment journey. Remember, it's crucial to communicate openly with your partner and healthcare provider about your concerns and seek support from friends, family, or professionals when needed.

Hudson Beauregard
Hudson Beauregard

Hi, I'm Hudson Beauregard, a pharmaceutical expert specializing in the research and development of cutting-edge medications. With a keen interest in studying various diseases and their treatments, I enjoy writing about the latest advancements in the field. I have dedicated my life to helping others by sharing my knowledge and expertise on medications and their effects on the human body. My passion for writing has led me to publish numerous articles and blog posts, providing valuable information to patients and healthcare professionals alike.

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