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Tag: TMP-SMX and warfarin

Trimethoprim-Sulfamethoxazole and Warfarin: How This Antibiotic Can Raise Your INR and Increase Bleeding Risk
1 Dec 2025
Daniel Walters

Trimethoprim-Sulfamethoxazole and Warfarin: How This Antibiotic Can Raise Your INR and Increase Bleeding Risk

Trimethoprim-sulfamethoxazole (Bactrim) can dangerously raise INR levels in people taking warfarin, increasing bleeding risk. Learn how this interaction works, who’s most at risk, and what to do if your INR spikes.

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